{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01197 has emerged as a multifunctional long non‐coding RNA with important tumor‐suppressive and anti‐inflammatory roles in different disease settings. In pancreatic ductal adenocarcinoma, LINC01197 is significantly downregulated in malignant tissues and its low expression is associated with poor prognosis. Functionally, LINC01197 is predominantly localized in the nucleus where it directly binds to β‐catenin, thereby disrupting the interaction between β‐catenin and TCF4 and ultimately inhibiting the Wnt/β‐catenin signaling pathway. This suppression of proliferative signaling contributes to reduced cell growth both in vitro and in vivo."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Moreover, in rheumatoid arthritis, LINC01197 expression is diminished in synovial tissues; its overexpression alleviates disease severity by sponging miR-150, which in turn upregulates THBS2 expression and inactivates the TLR4/NF-κB pathway, leading to reduced inflammation, lower proliferation, and enhanced apoptosis of fibroblast-like synoviocytes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Additionally, LINC01197 has been identified as part of a six-ferroptosis-related lncRNA signature in gastric cancer that can stratify patients into distinct risk groups, thereby serving as a prognostic indicator."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jing Ling, Fan Wang, Chuan Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FOXO1-regulated lncRNA LINC01197 inhibits pancreatic adenocarcinoma cell proliferation by restraining Wnt/β-catenin signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-019-1174-3"}], "href": "https://doi.org/10.1186/s13046-019-1174-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31027497"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31027497"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Y-H Jia, W-W Zheng, Z-H Ye "}, {"type": "b", "children": [{"type": "t", "text": "Clinical significance of CA 19.9 and LINC01197 in pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202003_20503"}], "href": "https://doi.org/10.26355/eurrev_202003_20503"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32196587"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32196587"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Feng Zhao, Jing Dong, Jialong Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibiting role of long non-coding RNA LINC01197 in inflammation in rheumatoid arthritis through the microRNA-150/THBS2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2020.112136"}], "href": "https://doi.org/10.1016/j.yexcr.2020.112136"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32540401"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32540401"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Qingfang Yue, Jun Bai, Fei Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel classification and risk model based on ferroptosis-related lncRNAs to predict oncologic outcomes for gastric cancer patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biochem Mol Toxicol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jbt.23052"}], "href": "https://doi.org/10.1002/jbt.23052"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35315178"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35315178"}]}]}]}