{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01198 is an oncogenic long non‐coding RNA that has been implicated in several cancers, most notably glioma, and is also associated with colorectal and bladder cancers. In glioma, multiple studies have demonstrated that LINC01198 is up‐regulated and correlates with poor patient outcomes. Mechanistically, LINC01198 promotes glioma cell proliferation and inhibits apoptosis by activating the PI3K/AKT pathway. It does so through a dual mechanism: in the cytoplasm, it functions as a molecular sponge for miR‑129‑5p to up‐regulate PIK3CA, while in the nucleus, it facilitates the assembly and recruitment of the REST/RCOR1/HDAC2 complex to suppress PTEN transcription (including effects further reinforced by its role as a scaffold for NEDD4‑1 to promote PTEN ubiquitination)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In another study, activation of STAT5A was shown to induce LINC01198 expression, which in turn stabilizes the RNA‐binding protein DGCR8, thereby modulating a set of microRNAs that further enhances glioma cell proliferation and motility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond glioma, LINC01198 is also implicated in colorectal cancer, where its up‐regulation promotes cell cycle progression and proliferation, while inhibiting apoptosis via modulation of the Notch signaling pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In the context of anaplastic gliomas, increased LINC01198 expression is part of a four‑lncRNA signature that correlates with higher tumor grade and poorer survival, further underlining its potential as a prognostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Reviews of lncRNA functions in glioma further highlight LINC01198’s promise as a diagnostic, prognostic, and therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Furthermore, in bladder cancer, a ceRNA network analysis identified LINC01198—along with other RNAs—as a high‐risk factor whose down‐regulation is associated with better overall survival, suggesting that its aberrant expression may contribute to tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings indicate that LINC01198 drives oncogenic processes in various cancers by modulating key signaling pathways such as PI3K/AKT and Notch, and by interacting with crucial regulatory proteins and microRNAs. Its multifaceted roles in tumor cell proliferation, survival, invasion, and chemoresistance underscore its potential as a valuable biomarker and therapeutic target across different cancer types.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yuan Xie, Yuan Cheng "}, {"type": "b", "children": [{"type": "t", "text": "LINC01198 facilitates gliomagenesis through activating PI3K/AKT pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "RNA Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15476286.2020.1755112"}], "href": "https://doi.org/10.1080/15476286.2020.1755112"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32378450"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32378450"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wei-Lin Chen, Hong-Jin Chen, Guo-Qiang Hou, et al. 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