{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01206 is a long non‐coding RNA that has emerged from recent transcriptomic analyses in two distinct pathological contexts. In a study of lung squamous cell carcinoma and lung adenocarcinoma tissues, LINC01206 was included among a panel of lncRNAs, although only one of the RNAs (SNHG1) was functionally characterized with respect to promoting cell proliferation, metastasis, and invasion via the TAp63/ZEB1 pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In a separate study examining placental tissues from pregnancies affected by prenatal opioid exposure leading to Neonatal Opioid Withdrawal Syndrome (NOWS), LINC01206 was identified as one of seven genes showing highly significant differential expression (FDR p‐value < 0.01), suggesting that its aberrant regulation may contribute to the complex gene networks underlying NOWS."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Although its precise molecular function remains to be fully elucidated, the dysregulated expression of LINC01206 in both lung cancer and NOWS contexts indicates that it may play a role in modulating key regulatory pathways involved in disease progression.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hong-Yan Zhang, Wei Yang, Fu-Shuang Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA SNHG1 regulates zinc finger E-box binding homeobox 1 expression by interacting with TAp63 and promotes cell metastasis and invasion in Lung squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2017.03.104"}], "href": "https://doi.org/10.1016/j.biopha.2017.03.104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28415044"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28415044"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Uppala Radhakrishna, Swapan K Nath, Sangeetha Vishweswaraiah, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Maternal opioid use disorder: Placental transcriptome analysis for neonatal opioid withdrawal syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genomics (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ygeno.2021.08.001"}], "href": "https://doi.org/10.1016/j.ygeno.2021.08.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34352367"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34352367"}]}]}]}