{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01210 has emerged as a regulatory long non‑coding RNA that contributes to disease progression in multiple contexts. In ovarian cancer, LINC01210 is markedly upregulated and is associated with metastasis and advanced disease stage. Functional studies show that its silencing reduces cellular proliferation, migration, and invasion through epigenetic mechanisms that involve the recruitment of EZH2 to suppress the expression of the tumor suppressor KLF4, ultimately correlating with poorer disease‐free and overall survival outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Similarly, in colorectal cancer, elevated LINC01210 expression is linked to metastatic potential and tumor advancement. Here, LINC01210 promotes proliferation, migration, and invasion by recruiting mixed lineage leukaemia protein‑1 (MLL1) to enhance H3K4 trimethylation on the SRSF3 promoter, thereby upregulating SRSF3 expression. Inhibition of SRSF3 attenuates these oncogenic properties, underscoring the epigenetic regulatory role of LINC01210 in colorectal tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond cancer, LINC01210 may also participate in the regulation of signaling pathways during venous congestion associated with cardiorenal syndromes. Analysis of dynamic long non‑coding RNA–mRNA co‑expression networks suggests that LINC01210 could influence the calcium signaling pathway by modulating the expression of key proteins such as plasma membrane calcium ATPase and G protein‑coupled receptor. This finding points to a broader functional repertoire for LINC01210 in pathophysiological conditions beyond cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chu Zhang, Jie Liu, Yang Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01210 accelerates proliferation, invasion and migration in ovarian cancer through epigenetically downregulating KLF4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2019.109431"}], "href": "https://doi.org/10.1016/j.biopha.2019.109431"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31514068"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31514068"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jia Luo, Kai Gao, Miao Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01210 promotes malignant phenotypes of colorectal cancer through epigenetically upregulating SRSF3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Res Pract (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prp.2022.153905"}], "href": "https://doi.org/10.1016/j.prp.2022.153905"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35462226"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35462226"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jinshun Li, Yuqin Xu, Jia Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dynamic co-expression network analysis of lncRNAs and mRNAs associated with venous congestion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2016.5480"}], "href": "https://doi.org/10.3892/mmr.2016.5480"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27431002"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27431002"}]}]}]}