{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n It is notable that none of the provided abstracts specifically describe or investigate the function of LINC01212. In contrast, a large body of the provided literature focuses on other oncogenic long non‐coding RNAs—most prominently SAMMSON—which have been extensively characterized in melanoma and several other malignancies. For instance, SAMMSON is frequently co‐amplified with MITF in melanoma, where it supports cancer cell growth and survival by modulating mitochondrial homeostasis through interaction with key effectors (for example, p32) that drive mitochondrial targeting and function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, SAMMSON has been shown to coordinate ribosomal RNA maturation and balance both mitochondrial and cytosolic protein synthesis by affecting the localization and activity of regulatory RNA‐binding proteins such as CARF. This dual regulatory mechanism contributes to enhanced cell proliferation and resistance to targeted therapies, underscoring the importance of disrupting mitochondrial and metabolic processes in cancer cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond cutaneous melanoma, similar oncogenic roles for SAMMSON have been reported in uveal melanoma and others—including hepatocellular carcinoma, glioblastoma, and triple‐negative breast cancer—where dysregulation of SAMMSON correlates with increased tumor proliferation, invasion, and chemoresistance, while its inhibition impairs mitochondrial translation and metabolic activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies underscore the emerging paradigm in which oncogenic long non‐coding RNAs modulate mitochondrial function, coordinate protein synthesis between compartments, and interface with stress response and survival pathways to support tumorigenesis. However, because none of the abstracts provided address LINC01212 directly, its potential contribution to these processes remains to be established and warrants further investigation.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Eleonora Leucci, Roberto Vendramin, Marco Spinazzi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Melanoma addiction to the long non-coding RNA SAMMSON."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature17161"}], "href": "https://doi.org/10.1038/nature17161"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27008969"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27008969"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Colin R Goding "}, {"type": "b", "children": [{"type": "t", "text": "Targeting the lncRNA SAMMSON Reveals Metabolic Vulnerability in Melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccell.2016.04.010"}], "href": "https://doi.org/10.1016/j.ccell.2016.04.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27165740"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27165740"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Roberto Vendramin, Yvessa Verheyden, Hideaki Ishikawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SAMMSON fosters cancer cell fitness by concertedly enhancing mitochondrial and cytosolic translation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41594-018-0143-4"}], "href": "https://doi.org/10.1038/s41594-018-0143-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30374086"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30374086"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Shujun Han, Yuwei Yan, Yibo Ren, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA SAMMSON Mediates Adaptive Resistance to RAF Inhibition in BRAF-Mutant Melanoma Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-20-3145"}], "href": "https://doi.org/10.1158/0008-5472.CAN-20-3145"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34087780"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34087780"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Shanna Dewaele, Louis Delhaye, Boel De Paepe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The long non-coding RNA SAMMSON is essential for uveal melanoma cell survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-021-02006-x"}], "href": "https://doi.org/10.1038/s41388-021-02006-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34508176"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34508176"}]}]}]}