{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies highlight a role for the long noncoding RNA LINC01213 in cancer progression. Although one study described an innovative method for mapping chromatin interactions without specifically addressing LINC01213 (1), other investigations have revealed its functional importance in several cancer types. In castration‐resistant prostate cancer, LINC01213 is upregulated in exosomes secreted by androgen‐independent cells, where it appears to activate the Wnt signaling pathway and facilitate the conversion of androgen‐dependent prostate cancer cells into an androgen‐independent state (2). In estrogen receptor–positive breast cancer, while LINC01213 upregulation in response to tamoxifen exposure does not directly alter proliferation or the expression of tamoxifen‐regulated genes, its modulation is associated with enhanced cellular migration and has prognostic significance (3). Furthermore, data mining analyses in melanoma have identified LINC01213 as significantly associated with disease incidence and progression, with its expression being modulated by BRAF mutation status; this suggests that LINC01213 may serve as a potential biomarker to distinguish between normal tissue, primary melanoma, and metastatic melanoma (4).\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings indicate that LINC01213 functions as a regulatory noncoding RNA influencing pathways related to cell migration, intercellular communication, and cellular transformation, thereby contributing to tumor progression and potentially serving as an informative biomarker across multiple cancer types.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Citations:."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ryan J Bourgo, Hari Singhal, Geoffrey L Greene "}, {"type": "b", "children": [{"type": "t", "text": "Capture of associated targets on chromatin links long-distance chromatin looping to transcriptional coordination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms12893"}], "href": "https://doi.org/10.1038/ncomms12893"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27634217"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27634217"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zhuifeng Guo, Xuwei Lu, Fan Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomal LINC01213 Plays a Role in the Transition of Androgen-Dependent Prostate Cancer Cells into Androgen-Independent Manners."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Oncol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2022/8058770"}], "href": "https://doi.org/10.1155/2022/8058770"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35310913"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35310913"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Martin Porsch, Esra Özdemir, Martin Wisniewski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Time resolved gene expression analysis during tamoxifen adaption of MCF-7 cells identifies long non-coding RNAs with prognostic impact."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "RNA Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15476286.2019.1581597"}], "href": "https://doi.org/10.1080/15476286.2019.1581597"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30760083"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30760083"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Han Yan, Dan Tan, Pan Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Multiple lncRNAs affect the incidence and development of melanoma]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhong Nan Da Xue Xue Bao Yi Xue Ban (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.11817/j.issn.1672-7347.2017.02.003"}], "href": "https://doi.org/10.11817/j.issn.1672-7347.2017.02.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28255113"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28255113"}]}]}]}