{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent investigations into long noncoding RNAs have highlighted LINC01214 as an emerging biomarker with disease‐specific implications. In a study of psoriasis, LINC01214 demonstrated excellent diagnostic efficacy while also being correlated with drug response. In this setting its expression was inversely associated with key pro‐inflammatory immune cell populations—including activated memory CD4 T cells, activated myeloid dendritic cells, neutrophils, macrophage M1, and T follicular helper cells—and positively correlated with regulatory T cells, suggesting that LINC01214 may play a role in modulating immune cell dynamics in inflammatory dermatoses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In non‐small cell lung cancer (NSCLC), LINC01214 was validated as one of several upregulated lncRNAs in tumor samples relative to adjacent normal tissues, reinforcing its potential utility as a diagnostic and prognostic biomarker that might contribute to lung cancer pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Notably, analyses in metastatic melanoma, which employed comprehensive competing endogenous RNA network approaches, and studies constructing genomic instability‐related lncRNA signatures did not report LINC01214 among their key candidates."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Together, these findings underscore that while LINC01214 may not be universally deregulated across all cancer types or related to all facets of epigenetic regulation, its dysregulation in psoriasis and NSCLC positions it as a promising candidate for further mechanistic studies and potential clinical application.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Feixiang Fan, Zhen Huang, Yongfeng Chen "}, {"type": "b", "children": [{"type": "t", "text": "Integrated analysis of immune-related long noncoding RNAs as diagnostic biomarkers in psoriasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PeerJ (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7717/peerj.11018"}], "href": "https://doi.org/10.7717/peerj.11018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33732554"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33732554"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Amelia Acha-Sagredo, Bubaraye Uko, Paschalia Pantazi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA dysregulation is a frequent event in non-small cell lung carcinoma pathogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Cancer (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41416-020-0742-9"}], "href": "https://doi.org/10.1038/s41416-020-0742-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32020063"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32020063"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Li-Xin Wang, Chuan Wan, Zheng-Bang Dong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrative Analysis of Long Noncoding RNA (lncRNA), microRNA (miRNA) and mRNA Expression and Construction of a Competing Endogenous RNA (ceRNA) Network in Metastatic Melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Sci Monit (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12659/MSM.913881"}], "href": "https://doi.org/10.12659/MSM.913881"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31004080"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31004080"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Longjun Yang, Guangran Guo, Xiangyang Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutation-Derived Long Noncoding RNA Signature Predicts Survival in Lung Adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2022.780631"}], "href": "https://doi.org/10.3389/fonc.2022.780631"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35372012"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35372012"}]}]}]}