{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01215 has emerged as a multifunctional long non‐coding RNA with distinct roles in immune regulation and tumor progression across various disease contexts. In a study of psoriasis, LINC01215 was identified as part of an immune‐related lncRNA panel that showed robust diagnostic efficacy and significant associations with drug response and immune cell infiltration—correlating negatively with activated memory CD4 T cells, activated myeloid dendritic cells, neutrophils, macrophage M1, and T follicular helper cells while correlating positively with regulatory T cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In cancer, enhancer‐associated LINC01215 exhibits high levels of activation-associated chromatin marks (H3K27ac and H3K4me1) and appears to modulate tumor–immune cell interactions by affecting the expression of major histocompatibility complex class I genes and CD47, suggesting a potential role in immune surveillance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In epithelial ovarian cancer, LINC01215 is upregulated and functions as an oncogenic driver by recruiting methylation-related proteins to suppress the expression of the tumor suppressor RUNX3. This repression leads to enhanced cell proliferation, migration, invasion, epithelial–mesenchymal transition, tumor growth, and lymph node metastasis; conversely, silencing LINC01215 restores RUNX3 expression and curtails these malignant behaviors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, in breast cancer, LINC01215 contributes to a seven-lncRNA prognostic signature and is intricately associated with multiple immune-related signaling pathways and variations in immune cell infiltration, thereby underscoring its utility as a prognostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Feixiang Fan, Zhen Huang, Yongfeng Chen "}, {"type": "b", "children": [{"type": "t", "text": "Integrated analysis of immune-related long noncoding RNAs as diagnostic biomarkers in psoriasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PeerJ (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7717/peerj.11018"}], "href": "https://doi.org/10.7717/peerj.11018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33732554"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33732554"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xin Li, Xu Pan, Hanxiao Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive characterization genetic regulation and chromatin landscape of enhancer-associated long non-coding RNAs and their implication in human cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brief Bioinform (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/bib/bbab401"}], "href": "https://doi.org/10.1093/bib/bbab401"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34581409"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34581409"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Wei Liu, Shu Tan, Xiaoxu Bai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LINC01215 promotes epithelial-mesenchymal transition and lymph node metastasis in epithelial ovarian cancer through RUNX3 promoter methylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.tranon.2021.101135"}], "href": "https://doi.org/10.1016/j.tranon.2021.101135"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34052627"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34052627"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Zijian Liu, Mi Mi, Xiaoqian Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A lncRNA prognostic signature associated with immune infiltration and tumour mutation burden in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.15762"}], "href": "https://doi.org/10.1111/jcmm.15762"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32967061"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32967061"}]}]}]}