{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In a study focused on colorectal cancer, gene expression profiling of 51 normal and 646 tumor tissues led to the identification of 80 survival‐related long noncoding RNAs (lncRNAs). Among these, a 15‐lncRNA signature—including LINC01219—was established as an independent prognostic indicator for overall survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although the detailed mechanistic role of LINC01219 was not separately elaborated upon, within this signature it is suggested to function as a competing endogenous RNA (ceRNA) that modulates key cancer‐related pathways. This ceRNA activity implies that LINC01219 may contribute to the regulatory networks governing tumor progression and could serve as a valuable biomarker for predicting patient outcomes in colorectal cancer.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xuning Wang, Jianguo Zhou, Maolin Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A 15-lncRNA signature predicts survival and functions as a ceRNA in patients with colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Manag Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/CMAR.S178732"}], "href": "https://doi.org/10.2147/CMAR.S178732"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30510449"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30510449"}]}]}]}