| Name | long intergenic non-protein coding RNA 1220 |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01220 is a long intergenic non‐coding RNA that has been implicated in modulating oncogenic processes. The findings presented in"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "indicate that LINC01220 is aberrantly upregulated in certain tumor tissues, where its elevated expression correlates with enhanced cellular proliferation, migration, and invasion. Functional studies suggest that LINC01220 may exert its oncogenic effects by acting as a molecular sponge for tumor‐suppressive microRNAs, thereby derepressing downstream target genes that promote tumor progression. Overall, these results position LINC01220 as a promising prognostic biomarker and a potential target for therapeutic intervention.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yong Li, Chengcai Kong, Chaoying Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knocking down of LINC01220 inhibits proliferation and induces apoptosis of endometrial carcinoma through silencing MAPK11."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20181794"}], "href": "https://doi.org/10.1042/BSR20181794"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31123170"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31123170"}]}]}]}
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| NCBI Gene ID | 731223 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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LINC01220 has 156 functional associations with biological entities spanning 2 categories (cell line, cell type or tissue, gene, protein or microRNA) extracted from 3 datasets.
Click the + buttons to view associations for LINC01220 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of LINC01220 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of LINC01220 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of LINC01220 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |