{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01224 is an oncogenic long non‐coding RNA that is frequently upregulated in multiple cancer types, including colorectal cancer, non‐small cell lung cancer (NSCLC), hepatocellular carcinoma (HCC), gastric cancer, melanoma, and colon cancer. Functionally, LINC01224 primarily acts as a competing endogenous RNA by “sponging” tumor‐suppressive microRNAs, thereby relieving repression of downstream oncogenes. For example, in colorectal cancer, LINC01224 is transcriptionally activated by YY1 and sequesters miR‐485‑5p, which in turn upregulates targets such as MYO6 to promote cell proliferation, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, in NSCLC, increased LINC01224 expression sponges miR‐2467 to enhance cell proliferation, invasion, and even contribute to radioresistance via modulation of chromatin interactions at the ZNF91 locus, thereby promoting stem cell–like properties."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In HCC, LINC01224 has been shown to bind miR‑330‑5p, which leads to increased expression of checkpoint kinase 1 (CHEK1) and enhanced malignant phenotypes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In gastric cancer, by sponging miR‐193a‑5p, LINC01224 upregulates CDK8 to promote cell viability, migration, and invasion while inhibiting apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Moreover, in melanoma, LINC01224 contributes to radioresistance and tumor progression through regulation of the miR‐193a‑5p/NR1D2 axis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", and in colon cancer, its interaction with miR‑485‑5p results in the upregulation of MCL1, fostering proliferation, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its mechanistic roles in promoting tumor cell growth, metastasis, and therapy resistance, elevated LINC01224 expression has been integrated into prognostic risk models for various cancers. These findings underscore its clinical relevance as a potential diagnostic biomarker and therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jingfeng Gu, Liang Dong, Yun Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01224 promotes colorectal cancer progression through targeting miR-485-5p/MYO6 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "World J Surg Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12957-021-02389-x"}], "href": "https://doi.org/10.1186/s12957-021-02389-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34535152"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34535152"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Lin Chen, Wei Chen, Changjie Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01224 Promotes Colorectal Cancer Progression by Sponging miR-2467."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Manag Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/CMAR.S281625"}], "href": "https://doi.org/10.2147/CMAR.S281625"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33542656"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33542656"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Shumei Xiao, Longhua Sun, Bin Ruan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LINC01224 promotes progression and cisplatin resistance in non-small lung cancer by sponging miR-2467."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pulm Pharmacol Ther (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.pupt.2021.102070"}], "href": "https://doi.org/10.1016/j.pupt.2021.102070"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34403779"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34403779"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Wenfan Fu, Jian Zhao, Weimin Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01224/ZNF91 Promote Stem Cell-Like Properties and Drive Radioresistance in Non-Small Cell Lung Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Manag Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/CMAR.S313744"}], "href": "https://doi.org/10.2147/CMAR.S313744"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34285587"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34285587"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Dan Gong, Peng-Cheng Feng, Xing-Fei Ke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing Long Non-coding RNA LINC01224 Inhibits Hepatocellular Carcinoma Progression via MicroRNA-330-5p-Induced Inhibition of CHEK1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Ther Nucleic Acids (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.omtn.2019.10.007"}], "href": "https://doi.org/10.1016/j.omtn.2019.10.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31902747"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31902747"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Hui Sun, Jihong Yan, Guangyu Tian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01224 accelerates malignant transformation via MiR-193a-5p/CDK8 axis in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.3726"}], "href": "https://doi.org/10.1002/cam4.3726"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33655711"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33655711"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yu Cui, Yi Zheng, Yue Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01224 facilitates the proliferation and inhibits the radiosensitivity of melanoma cells through the miR-193a-5p/NR1D2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Kaohsiung J Med Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/kjm2.12467"}], "href": "https://doi.org/10.1002/kjm2.12467"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34783160"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34783160"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Danping Yuan, Yanan Zhu "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of LINC01224 Suppresses Colon Cancer Progression by Sponging miR-485-5p to Downregulate MCL1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Manag Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/CMAR.S289024"}], "href": "https://doi.org/10.2147/CMAR.S289024"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34675675"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34675675"}]}]}]}