{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long intergenic non‐coding RNA DYNLRB2‐2 (LINC01228) has emerged as an important regulator of cholesterol homeostasis and inflammatory responses in macrophage‐derived foam cells. In vitro studies demonstrate that exposure to oxidized LDL triggers the upregulation of LINC01228, which in turn induces the expression of G protein‐coupled receptor 119 (GPR119) and the cholesterol transporter ABCA1 via glucagon‐like peptide receptor signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Enhanced ABCA1 expression promotes apoA-I–mediated cholesterol efflux, thereby reducing intracellular cholesterol accumulation and mitigating proinflammatory cytokine release in foam cells. Further investigations indicate that modulation of LINC01228 can affect cholesterol metabolism through regulation of toll‐like receptor 2 (TLR2) expression"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", underscoring its role in the control of lipid metabolism. In addition, LINC01228 is grouped among a broader class of long noncoding RNAs that orchestrate gene networks involved in hepatic lipid regulation and metabolic disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Together, these findings suggest that LINC01228 contributes to the maintenance of lipid balance and the attenuation of inflammatory pathways in atherosclerotic pathologies, making it a promising target for therapeutic intervention in cardiovascular and metabolic disorders.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yan-Wei Hu, Jun-Yao Yang, Xin Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A lincRNA-DYNLRB2-2/GPR119/GLP-1R/ABCA1-dependent signal transduction pathway is essential for the regulation of cholesterol homeostasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Lipid Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1194/jlr.M044669"}], "href": "https://doi.org/10.1194/jlr.M044669"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24493833"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24493833"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yongqiang Li, Shuxin Shen, Shoukun Ding, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LincRNA DYN-LRB2-2 upregulates cholesterol efflux by decreasing TLR2 expression in macrophages."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.26352"}], "href": "https://doi.org/10.1002/jcb.26352"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28815701"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28815701"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yulan Zhao, Jianguo Wu, Suthat Liangpunsakul, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Non-coding RNA in Liver Metabolism and Disease: Current Status."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Liver Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.livres.2017.09.001"}], "href": "https://doi.org/10.1016/j.livres.2017.09.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29576888"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29576888"}]}]}]}