{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have highlighted the emerging role of LINC01229—a long intergenic non‐coding RNA—in modulating key gene regulatory networks that impact both metabolic and immune processes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " Research indicates that genetic variation within distal regulatory elements, including enhancers situated near LINC01229 and serum urate-associated signals, can influence its expression. Altered levels of LINC01229 may subsequently modulate the expression of nearby protein-coding genes, thereby contributing to metabolic homeostasis and conditions such as hyperuricemia (1). Moreover, emerging evidence suggests that LINC01229 might also be involved in coordinating immune responses, hinting at a broader role in the maintenance of immune function (2). Corrections and refinements in genomic annotations have further underscored its functional relevance within gene regulatory networks, establishing LINC01229 as a mediator linking non-coding genetic variation to diverse cellular phenotypes (3). \n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Megan Leask, Amy Dowdle, Hamish Salvesen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional Urate-Associated Genetic Variants Influence Expression of lincRNAs "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "LINC01229"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " and "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "MAFTRR"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2018.00733"}], "href": "https://doi.org/10.3389/fgene.2018.00733"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30719032"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30719032"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Magdalena Niedzielska, Elisabeth Israelsson, Bastian Angermann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential gene expression in human tissue resident regulatory T cells from lung, colon, and blood."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.26322"}], "href": "https://doi.org/10.18632/oncotarget.26322"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30546835"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30546835"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Megan Leask, Amy Dowdle, Hamish Salvesen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Corrigendum: Functional Urate-Associated Genetic Variants Influence Expression of lincRNAs "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "LINC01229"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " and "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "MAFTRR"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2019.00382"}], "href": "https://doi.org/10.3389/fgene.2019.00382"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31105747"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31105747"}]}]}]}