{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01230 is a long intergenic noncoding RNA that has emerged as a potential regulatory molecule in both oncologic and cardiovascular contexts. In renal cell carcinoma, LINC01230 was identified among the top down‐regulated lncRNAs in tumor tissue compared with non-tumor counterparts, suggesting that its altered expression may be related to tumor biology and could serve as a diagnostic or prognostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In endometrial cancer, LINC01230 was one of several lncRNAs evaluated for association with the disease, although the study primarily highlighted alterations in another lncRNA (LINC01468); the inclusion of LINC01230 in this panel underscores an active interest in its potential involvement in gynecologic malignancies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n More strikingly, functional studies in vascular endothelial cells have revealed that LINC01230 is transcriptionally regulated by PPARγ. Binding of PPARγ to two upstream regions of the LINC01230 promoter not only increases its expression but also mediates protective effects against ox-LDL-induced endothelial dysfunction by modulating Akt phosphorylation. These findings indicate that LINC01230 plays an important role in maintaining endothelial function and could serve as a novel modifier in PPARγ-mediated signaling pathways relevant to cardiovascular health."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Julia Bohosova, Marek Kasik, Adela Kubickova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA PVT1 is increased in renal cell carcinoma and affects viability and migration in vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Lab Anal (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcla.24442"}], "href": "https://doi.org/10.1002/jcla.24442"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35441392"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35441392"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jan Bieńkiewicz, Hanna Romanowicz, Bożena Szymańska, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of lncRNA sequences: FAM3D-AS1, LINC01230, LINC01315 and LINC01468 in endometrial cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-022-09426-2"}], "href": "https://doi.org/10.1186/s12885-022-09426-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35351056"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35351056"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Longmei Liu, Zhongchao Wang, Junqing Jia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Linc01230, transcriptionally regulated by PPARγ, is identified as a novel modifier in endothelial function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.11.045"}], "href": "https://doi.org/10.1016/j.bbrc.2018.11.045"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30454889"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30454889"}]}]}]}