{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In hepatocellular carcinoma (HCC), LINC01231 has been identified as one of nine ferroptosis‐related long non‐coding RNAs that are differentially expressed in tumor tissues compared to normal hepatic tissues (1). Its inclusion in a prognostic signature suggests that LINC01231 contributes to a network influencing cell death processes and the tumor immune microenvironment. In this signature, LINC01231, alongside other lncRNAs, is associated with pathways regulating tumor necrosis factor α/nuclear factor kappa‐B, interleukin‑2/signal transducers and activators of transcription 5, and cytokine/cytokine receptor signaling. These findings indicate that LINC01231 may play a role in modulating immune cell infiltration—including alterations in resting memory CD4⁺ T cells, follicular helper T cells, regulatory T cells, and M0 macrophages—as well as in the regulation of immune checkpoint molecules such as B7H3, thereby impacting HCC progression and patient prognosis (1)."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zhijie Xu, Bi Peng, Qiuju Liang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Construction of a Ferroptosis-Related Nine-lncRNA Signature for Predicting Prognosis and Immune Response in Hepatocellular Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2021.719175"}], "href": "https://doi.org/10.3389/fimmu.2021.719175"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34603293"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34603293"}]}]}]}