{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Multiple independent studies have demonstrated that the long non‐coding RNA LINC01234 is frequently overexpressed across a range of human cancers – including non‐small cell lung cancer (NSCLC), oral squamous cell carcinoma, esophageal cancer, triple‐negative breast cancer (TNBC), colorectal cancer, multiple myeloma, hepatocellular carcinoma (HCC), clear cell renal cell carcinoma (ccRCC), and gastric cancer – and its elevated levels are generally associated with aggressive clinicopathological features and poorer patient outcomes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Mechanistically, LINC01234 has been shown to function predominantly as an oncogenic competing endogenous RNA. In NSCLC, one study reported that LINC01234 interacts with the RNA‐binding protein HNRNPA2B1 to recruit DGCR8 and promote the processing of specific microRNA precursors (including pri‐miR‐106b), which in turn leads to downregulation of the tumor suppressor CRY2 and a subsequent increase in c‐Myc expression, establishing a positive‐feedback loop that promotes tumor growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In parallel, another investigation in NSCLC found that LINC01234 is transcriptionally induced by SP1 and acts as a molecular sponge for miR‐140, thereby enhancing OTUB1 expression to drive proliferation and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In oral squamous cell carcinoma, LINC01234 exerts an oncogenic effect by sequestering miR‐637, which leads to increased levels of NUPR1 and, consequently, promotes malignant cell behaviors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Similarly, in esophageal cancer, LINC01234 binds miR‐193a‐5p to relieve repression of CCNE1, thereby facilitating cell cycle progression and tumor growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In TNBC, LINC01234 is reported to sponge miR‐525‐5p, resulting in upregulation of MEIS2 and activation of the Wnt/β‐catenin pathway, which together enhance cell proliferation, migration, invasion, and epithelial‐mesenchymal transition."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In colorectal cancer, two distinct studies have elucidated its oncogenic role: one demonstrated that LINC01234 sponges miR‐1284, leading to derepression of TRAF6 and promotion of cell proliferation and invasion"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", while another found that LINC01234 acts as a competing endogenous RNA for miR‐642a‐5p, thereby elevating SHMT2 expression to drive serine/glycine metabolism and cancer progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In multiple myeloma, LINC01234 has been shown to sponge miR‐124‐3p, resulting in increased expression of GRB2—a protein that supports oncogenic signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In HCC, LINC01234 has dual roles; one study revealed that by binding miR‐31‐5p, it facilitates upregulation of MAGEA3, thereby enhancing invasion, proliferation, and resistance to cisplatin"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ", while another study showed that LINC01234 downregulates ASS1 to reprogram aspartate metabolism, activating the mTOR pathway and promoting drug resistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Furthermore, in ccRCC, LINC01234 is incorporated into prognostic signatures and appears to contribute to genomic instability and drive tumor progression through modulation of the HIF‐2α pathway"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": ", and in gastric cancer, its upregulation correlates with differentiation status and cancer‐associated pathways such as cell cycle control and mismatch repair."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, LINC01234 functions as a multifaceted oncogenic driver in diverse cancers by modulating key microRNA networks and downstream effectors that control cell proliferation, apoptosis, migration, invasion, metabolism, and chemoresistance. Its consistent overexpression and involvement in critical regulatory axes underscore its potential as a prognostic biomarker and therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zhenyao Chen, Xin Chen, Tianyao Lei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrative Analysis of NSCLC Identifies LINC01234 as an Oncogenic lncRNA that Interacts with HNRNPA2B1 and Regulates miR-106b Biogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Ther (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ymthe.2020.03.010"}], "href": "https://doi.org/10.1016/j.ymthe.2020.03.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32246902"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32246902"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jing-Jing Xie, Qun-Yi Guo, Jian-Ying Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SP1-mediated overexpression of lncRNA LINC01234 as a ceRNA facilitates non-small-cell lung cancer progression via regulating OTUB1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.28848"}], "href": "https://doi.org/10.1002/jcp.28848"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31106421"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31106421"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Wenjie Huang, Jia Cao, Xuxia Peng "}, {"type": "b", "children": [{"type": "t", "text": "LINC01234 facilitates growth and invasiveness of oral squamous cell carcinoma through regulating the miR-637/NUPR1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2019.109507"}], "href": "https://doi.org/10.1016/j.biopha.2019.109507"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31590125"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31590125"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jun Ma, Li-Na Han, Jian-Rui Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA LINC01234 silencing exerts an anti-oncogenic effect in esophageal cancer cells through microRNA-193a-5p-mediated CCNE1 downregulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Oncol (Dordr) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13402-019-00493-5"}], "href": "https://doi.org/10.1007/s13402-019-00493-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32130660"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32130660"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Feng Xiao, Hongyao Jia, Di Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01234 aggravates cell growth and migration of triple-negative breast cancer by activating the Wnt pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Environ Toxicol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/tox.23318"}], "href": "https://doi.org/10.1002/tox.23318"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34173712"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34173712"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xin Liao, Wei Zhan, Jiandong Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA LINC01234 promoted cell proliferation and invasion via miR-1284/TRAF6 axis in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.29618"}], "href": "https://doi.org/10.1002/jcb.29618"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31904146"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31904146"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Zhiyun He, Jie Dang, Ailin Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of LINC01234 and MIR210HG as novel prognostic signature for colorectal adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.27424"}], "href": "https://doi.org/10.1002/jcp.27424"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30362555"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30362555"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Xueyan Chen, Yin Liu, Zihua Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01234 promotes multiple myeloma progression by regulating miR-124-3p/GRB2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Transl Res (2019)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31737211"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31737211"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yunhao Chen, Hui Zhao, Haibo Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01234/MicroRNA-31-5p/MAGEA3 Axis Mediates the Proliferation and Chemoresistance of Hepatocellular Carcinoma Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Ther Nucleic Acids (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.omtn.2019.10.035"}], "href": "https://doi.org/10.1016/j.omtn.2019.10.035"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31838274"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31838274"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Muhua Chen, Chunfeng Zhang, Wei Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA LINC01234 promotes hepatocellular carcinoma progression through orchestrating aspartate metabolic reprogramming."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Ther (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ymthe.2022.02.020"}], "href": "https://doi.org/10.1016/j.ymthe.2022.02.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35192933"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35192933"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Feilong Yang, Cheng Liu, Guojiang Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LINC01234 regulates proliferation, migration and invasion via HIF-2α pathways in clear cell renal cell carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PeerJ (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7717/peerj.10149"}], "href": "https://doi.org/10.7717/peerj.10149"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33088626"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33088626"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Yinyin Zhu, Cong Luo, Arshad Ali Korakkandan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Function and regulation annotation of up-regulated long non-coding RNA LINC01234 in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Lab Anal (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcla.23210"}], "href": "https://doi.org/10.1002/jcla.23210"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32011780"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32011780"}]}]}]}