{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have highlighted the oncogenic role of LINC01235 in multiple cancer types. In gastric cancer, elevated LINC01235 expression has been shown to promote cell migration and invasion by inducing epithelial–mesenchymal transition (EMT), in part through a positive feedback loop with the transcription factor TWIST2 and its downstream mediator THBS2."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In breast cancer, LINC01235 is significantly upregulated and correlates with advanced disease characteristics including stage, estrogen receptor status, and lymph node involvement; mechanistic studies further suggest its involvement in regulating proliferation, migration, and invasion potentially via pathways such as p53 signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, in stomach adenocarcinoma, LINC01235 has emerged as an optimal diagnostic and prognostic biomarker; its overexpression is associated with poor survival outcomes and enrichment in key oncogenic pathways including the cell cycle, DNA replication, ECM–receptor interaction, and p53 signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Collectively, these findings underscore the clinical and functional significance of LINC01235 as a driver of tumor progression and a potential therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yu-En Tan, Yao Xing, Ban-Lai Ran, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01235-TWIST2 feedback loop facilitates epithelial-mesenchymal transition in gastric cancer by inhibiting THBS2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.103979"}], "href": "https://doi.org/10.18632/aging.103979"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33206629"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33206629"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Cheng Zhang, Yu Liang, Chun-Dong Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The novel role and function of LINC01235 in metastasis of gastric cancer cells by inducing epithelial-mesenchymal transition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genomics (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ygeno.2021.03.027"}], "href": "https://doi.org/10.1016/j.ygeno.2021.03.027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33771634"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33771634"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zhe Li, Zheng Qian, Fei Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Key lncRNA-mRNA Pairs and Functional lncRNAs in Breast Cancer by Integrative Analysis of TCGA Data."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2021.709514"}], "href": "https://doi.org/10.3389/fgene.2021.709514"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34490040"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34490040"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ye Zhao, Lixiao Liu, Jinduo Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Construction and Verification of a Hypoxia-Related 4-lncRNA Model for Prediction of Breast Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Gen Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/IJGM.S322007"}], "href": "https://doi.org/10.2147/IJGM.S322007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34429643"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34429643"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Qun Li, Xiaofeng Liu, Jia Gu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Screening lncRNAs with diagnostic and prognostic value for human stomach adenocarcinoma based on machine learning and mRNA-lncRNA co-expression network analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Genet Genomic Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mgg3.1512"}], "href": "https://doi.org/10.1002/mgg3.1512"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33002344"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33002344"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xiulei Zhang, Peiming Zheng, Zhen Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Somatic Mutation Landscape and RNA Prognostic Markers in Stomach Adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Onco Targets Ther (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/OTT.S263733"}], "href": "https://doi.org/10.2147/OTT.S263733"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32801780"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32801780"}]}]}]}