{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Research on cancer‐related noncoding RNAs has revealed distinct roles for long intergenic noncoding RNAs (lincRNAs) in tumorigenesis. In a study of gliomas, extensive analyses of CNV‐driven dysregulated ceRNA networks involving hundreds of lncRNAs were performed, although LINC01239 was not specifically singled out in that context (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In contrast, in the setting of HBV‐infected intrahepatic cholangiocarcinoma, a distinctive intergenic insertion on chromosome 9p21.3—located between DMRTA1 and LINC01239—was shown to exert oncogenic effects through activation of the mTOR/4EBP/S6K pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " This insertion event suggests that LINC01239 (or its genomic region) may be implicated in mediating aberrant signaling cascades, thereby contributing to tumor development. Collectively, while large‐scale ceRNA network analyses in gliomas underscore the overall importance of dysregulated lncRNAs in cancer, the specific identification of an insertion event involving the LINC01239 locus in HBV‐associated cholangiocarcinomas highlights its potential role as a mediator of oncogenic mTOR pathway activation.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jinyuan Xu, Xiaobo Hou, Lin Pang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Dysregulated Competitive Endogenous RNA Networks Driven by Copy Number Variations in Malignant Gliomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2019.01055"}], "href": "https://doi.org/10.3389/fgene.2019.01055"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31719831"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31719831"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jihyun An, Deokhoon Kim, Bora Oh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive characterization of viral integrations and genomic aberrations in HBV-infected intrahepatic cholangiocarcinomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.32135"}], "href": "https://doi.org/10.1002/hep.32135"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34478159"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34478159"}]}]}]}