{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe abstracts provided do not contain any information regarding LINC01247. Instead, one study (PubMed:"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "describes how the loss of ABAT in basal‐like breast cancer leads to increased GABA production. This, in turn, elevates intracellular Ca2+ via activation of the GABA-A receptor and subsequent activation of the NFAT1 transcription factor, contributing to enhanced tumorigenicity and metastasis. \n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nA second study (PubMed:"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "investigates the effects of propionate accumulation in the brain, showing that propionate inhibits GABA transaminase. This inhibition results in increased GABA levels, reduced neuronal glucose metabolism, and ultimately leads to transient lethargy and a greater susceptibility of GABAergic neurons to degeneration, as observed in propionic acidemia.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBecause neither abstract mentions or examines LINC01247, its function in these contexts remains undetermined based on the provided literature. Further research would be required to elucidate any potential role of LINC01247 in relation to the GABA metabolism and signaling pathways highlighted in these studies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xingyu Chen, Qianhua Cao, Ruocen Liao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of ABAT-Mediated GABAergic System Promotes Basal-Like Breast Cancer Progression by Activating Ca"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "2+"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": "-NFAT1 Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Theranostics (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/thno.29407"}], "href": "https://doi.org/10.7150/thno.29407"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30662552"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30662552"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Cecilie Morland, Anne-Sofie Frøland, Mi Nguyen Pettersen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Propionate enters GABAergic neurons, inhibits GABA transaminase, causes GABA accumulation and lethargy in a model of propionic acidemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BCJ20170814"}], "href": "https://doi.org/10.1042/BCJ20170814"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29339464"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29339464"}]}]}]}