{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01249 is a long non‐coding RNA that appears to be a component of a multi‐lncRNA signature associated with metastatic risk in breast cancer (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In this study, several lncRNAs were repurposed from microarray data and combined into a prognostic model that could stratify patients by metastasis‐free survival; although the study did not single out LINC01249 for functional dissection, its inclusion in the signature suggests that it may play a role in influencing pathways associated with tumor metastasis. Moreover, emerging evidence indicates that such non‐coding RNAs can be subjected to epigenetic modifications—as illustrated by metformin‐induced changes in DNA methylation profiles in white blood cells"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "—which may in turn affect their transcriptional activity and regulatory functions in cellular energy homeostasis, inflammatory responses, and tumorigenesis. Finally, studies identifying genetic loci associated with circulating hormone levels"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "further underscore the potential interplay between non‐coding RNAs and systemic endocrine regulation. Together, these findings imply that LINC01249 may be involved in critical regulatory networks that modulate metastatic potential in cancer and could be influenced by epigenetic as well as genetic factors, highlighting its promise as both a biomarker and a potential therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jie Sun, Xihai Chen, Zhenzhen Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A potential prognostic long non-coding RNA signature to predict metastasis-free survival of breast cancer patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep16553"}], "href": "https://doi.org/10.1038/srep16553"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26549855"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26549855"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ilze Elbere, Ivars Silamikelis, Monta Ustinova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Significantly altered peripheral blood cell DNA methylation profile as a result of immediate effect of metformin use in healthy individuals."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Epigenetics (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13148-018-0593-x"}], "href": "https://doi.org/10.1186/s13148-018-0593-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30545422"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30545422"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Liang Huang, Fenghua Bai, Yutian Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Preliminary study of genome-wide association identified novel susceptibility genes for thyroid-related hormones in Chinese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Genomics (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13258-021-01165-1"}], "href": "https://doi.org/10.1007/s13258-021-01165-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34533693"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34533693"}]}]}]}