{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have implicated the long intergenic non‐coding RNA LINC01250 in modulating survival outcomes among individuals with coronary artery disease (CAD), an age‐associated condition linked to increased mortality risk. In one genome‐wide screening study, variants in or near LINC01250 were identified as candidate predictors of all‐cause mortality in high‐risk CAD patients, suggesting that this locus may influence key biological pathways related to aging, vascular injury, and cellular response mechanisms."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Complementary evidence from additional research further supports a potential functional role for LINC01250, although the precise molecular mechanisms remain to be fully elucidated."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Together, these findings highlight LINC01250 as a promising target for further investigation into its contributions to disease progression and mortality risk in CAD.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jennifer R Dungan, Xue Qin, Melissa Hurdle, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-Wide Variants Associated With Longitudinal Survival Outcomes Among Individuals With Coronary Artery Disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2021.661497"}], "href": "https://doi.org/10.3389/fgene.2021.661497"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34140969"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34140969"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "K Matlawska-Wasowska, H Kang, M Devidas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MLL rearrangements impact outcome in HOXA-deregulated T-lineage acute lymphoblastic leukemia: a Children's Oncology Group Study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leukemia (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/leu.2016.60"}], "href": "https://doi.org/10.1038/leu.2016.60"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26952838"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26952838"}]}]}]}