{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent genomic studies in pediatric B‐cell precursor acute lymphoblastic leukemia and lung squamous cell carcinoma have underscored the importance of non‐coding RNAs in both risk stratification and tumor biology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the context of pediatric ALL, panel‐based RNA sequencing combined with array CGH has been instrumental in detecting chromosomal aberrations that facilitate risk‐adapted therapy. Although the study primarily focused on identifying chromosomal lesions such as alterations in IKZF1, the analytic framework also supports the detection of deregulated non‐coding transcripts, suggesting that lncRNAs like LINC01251 may contribute to the complex genomic landscape underlying disease progression."}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In lung squamous cell carcinoma, integrated analysis of RNA sequencing profiles and copy number variation data has revealed that a subset of long non‐coding RNAs is modulated by genomic copy number changes, positioning them as promising biomarkers for clinical applications."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Among these candidate lncRNAs, LINC01251 has emerged as a potential player in modulating gene regulatory networks associated with tumorigenesis. Although its precise mechanistic role remains to be fully elucidated, current evidence indicates that LINC01251, together with other CNV‐regulated lncRNAs, could serve as a prognostic indicator and possibly a therapeutic target given its involvement in pathways that influence cancer progression."}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings highlight the dual relevance of LINC01251 in diverse malignancies—both as a component of diagnostic workflows in pediatric ALL and as a regulator within gene networks in lung squamous cell carcinoma—emphasizing its potential utility as a biomarker bridging genomic alterations with clinical outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Maximilian Schieck, Jana Lentes, Kathrin Thomay, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Implementation of RNA sequencing and array CGH in the diagnostic workflow of the AIEOP-BFM ALL 2017 trial on acute lymphoblastic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Hematol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00277-020-03953-3"}], "href": "https://doi.org/10.1007/s00277-020-03953-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32078009"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32078009"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jinfeng Ning, Fengjiao Wang, Kaibin Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterizing the Copy Number Variation of Non-Coding RNAs Reveals Potential Therapeutic Targets and Prognostic Markers of LUSC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2021.779155"}], "href": "https://doi.org/10.3389/fgene.2021.779155"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34925461"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34925461"}]}]}]}