{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01255 is a long non‐coding RNA that is highly expressed in bone marrow cells of acute myeloid leukemia (AML) patients and CD34⁺ cells of MDS-AML patients, where its elevated levels correlate with poorer survival outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Functionally, LINC01255 interacts with BMI1 to repress the transcription of MCP-1, thereby activating the p53-p21 signaling pathway. This activation modulates key cellular processes by inhibiting senescence in human mesenchymal stromal cells and reducing the proliferation of AML cells. These findings reveal that LINC01255 plays a critical role in the regulation of cell senescence and proliferation within the context of hematopoietic malignancies, and they underscore its potential as a therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Q Liu, J Dong, J Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01255 combined with BMI1 to regulate human mesenchymal stromal senescence and acute myeloid leukemia cell proliferation through repressing transcription of MCP-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Transl Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12094-020-02505-5"}], "href": "https://doi.org/10.1007/s12094-020-02505-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33405050"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33405050"}]}]}]}