{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01257 is a long non‐coding RNA with emerging clinical significance in distinct disease settings. In primary biliary cholangitis (PBC), its plasma expression is significantly up‐regulated compared to healthy controls, indicating its potential as a novel diagnostic biomarker when assessed alongside other markers such as S100A6 mRNA, LINC00312, and LINC00472."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In contrast, in pediatric acute myeloid leukemia (AML), particularly in patients harboring the t(8;21) translocation, LINC01257 is selectively and aberrantly expressed, functioning as an oncogenic driver. This specificity has been exploited therapeutically by silencing LINC01257 using siRNA‐loaded lipid nanoparticles, thereby representing a promising targeted approach for AML treatment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xi-Hua Dong, Di Dai, Zhi-Dong Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "S100 calcium binding protein A6 and associated long noncoding ribonucleic acids as biomarkers in the diagnosis and staging of primary biliary cholangitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "World J Gastroenterol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3748/wjg.v27.i17.1973"}], "href": "https://doi.org/10.3748/wjg.v27.i17.1973"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34007134"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34007134"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Patrick Connerty, Ernest Moles, Charles E de Bock, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Development of siRNA-Loaded Lipid Nanoparticles Targeting Long Non-Coding RNA LINC01257 as a Novel and Safe Therapeutic Approach for t(8;21) Pediatric Acute Myeloid Leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmaceutics (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/pharmaceutics13101681"}], "href": "https://doi.org/10.3390/pharmaceutics13101681"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34683974"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34683974"}]}]}]}