{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01264 appears to function as a long intergenic noncoding RNA that is part of regulatory networks associated with cancer. In one study examining the tumor suppressor PinX1 in breast cancer, comprehensive transcriptomic profiling revealed that a subset of lincRNAs—including LINC01264—are coregulated with nearby mRNAs, suggesting that these RNAs may contribute to modulating cell cycle progression and proliferation through cis‐regulatory mechanisms."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In a complementary study focused on neuroblastoma, a novel computational metric was employed to identify risk-dependent lincRNAs that reflect enhancer activity; in this context, lincRNAs similar to LINC01264 were prioritized as biomarkers with prognostic significance and as potential modulators of local gene expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Together, these findings suggest that LINC01264 may serve as an enhancer-templated RNA involved in cis-regulatory control of gene expression, thereby impacting tumorigenesis and representing a promising target for further investigation in cancer biology.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Rong Shi, Jue-Yu Zhou, Hui Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The role of PinX1 in growth control of breast cancer cells and its potential molecular mechanism by mRNA and lncRNA expression profiles screening."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2014/978984"}], "href": "https://doi.org/10.1155/2014/978984"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24672800"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24672800"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zhezhen Wang, John M Cunningham, Xinan H Yang "}, {"type": "b", "children": [{"type": "t", "text": "CisPi: a transcriptomic score for disclosing cis-acting disease-associated lincRNAs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioinformatics (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/bioinformatics/bty574"}], "href": "https://doi.org/10.1093/bioinformatics/bty574"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30423099"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30423099"}]}]}]}