{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01268 appears to be a multifunctional long non‐coding RNA with diverse roles in both oncogenesis and neural regulation. In glioma, for example, the transcript—also referred to as LOC285758—is epigenetically upregulated across various subtypes and correlates with tumor grade, suggesting its potential utility as an early diagnostic marker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In hepatocellular carcinoma, high LINC01268 expression is associated with moderate to poor differentiation, enhanced cell proliferation, and reduced overall patient survival; mechanistic studies indicate that it regulates the expression of MAP3K7, thereby contributing to tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In the setting of acute myeloid leukemia, LINC01268 has been shown to function as a competing endogenous RNA by sponging miR-217, which in turn de-represses SOS1 expression and promotes cell viability and cell cycle progression while inhibiting apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, altered brain expression of LINC01268 has been linked to traits of aggression and a predisposition for suicide by violent methods, implying a role in emotional regulation and behavioral control."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings position LINC01268 as a promising biomarker and potential therapeutic target in multiple disease contexts, from glioma and hepatocellular carcinoma to acute myeloid leukemia and neuropsychiatric conditions.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Alenka Matjasic, Mara Popovic, Bostjan Matos, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of LOC285758, a Potential Long Non-coding Biomarker, is Methylation-dependent and Correlates with Glioma Malignancy Grade."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Radiol Oncol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1515/raon-2017-0004"}], "href": "https://doi.org/10.1515/raon-2017-0004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28959170"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28959170"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiuli Jin, Weixin Fu, Dan Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High Expression of LINC01268 is Positively Associated with Hepatocellular Carcinoma Progression via Regulating MAP3K7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Onco Targets Ther (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/OTT.S295814"}], "href": "https://doi.org/10.2147/OTT.S295814"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33727826"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33727826"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Beili Chen, Yuchuan Li, Yuwei Nie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LINC01268 promotes cell growth and inhibits cell apoptosis by modulating miR-217/SOS1 axis in acute myeloid leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Braz J Med Biol Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1590/1414-431X20209299"}], "href": "https://doi.org/10.1590/1414-431X20209299"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32609259"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32609259"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Giovanna Punzi, Gianluca Ursini, Giovanna Viscanti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of a Noncoding RNA Postmortem With Suicide by Violent Means and In Vivo With Aggressive Phenotypes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Psychiatry (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopsych.2018.11.002"}], "href": "https://doi.org/10.1016/j.biopsych.2018.11.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30600091"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30600091"}]}]}]}