{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNA LINC01270 appears to play an oncogenic role in several cancer types, although its underlying mechanisms vary. In esophageal cancer, LINC01270 is up‐regulated and functions by recruiting DNA methyltransferases (DNMT1, DNMT3A, and DNMT3B) to promote methylation of the GSTP1 promoter, thereby facilitating cell proliferation, migration, invasion, and resistance to 5‐fluorouracil treatment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In gastric cancer, increased LINC01270 expression similarly promotes malignant progression by acting as a competing endogenous RNA (ceRNA) that sequesters miR-326, which in turn results in up-regulation of EFNA3 and subsequent enhancement of cell proliferation, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In triple-negative breast cancer, elevated levels of LINC01270 are associated with poorer overall and disease-free survival, suggesting that it may serve as a prognostic biomarker and potential therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Finally, its differential expression in lung adenocarcinoma has highlighted LINC01270 as one of several lncRNAs with high diagnostic potential, contributing to the development of accurate classification models for this cancer type."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Nuo Li, Zhifeng Zhao, Feng Miao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing of long non-coding RNA LINC01270 inhibits esophageal cancer progression and enhances chemosensitivity to 5-fluorouracil by mediating GSTP1methylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Gene Ther (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41417-020-00232-1"}], "href": "https://doi.org/10.1038/s41417-020-00232-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33199829"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33199829"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Bing Jiang, Kankan Yang, Chao Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA LINC01270 aggravates the progression of gastric cancer through modulation of miR-326/EFNA3 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2022.2054204"}], "href": "https://doi.org/10.1080/21655979.2022.2054204"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35345980"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35345980"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jie Ping, Shuya Huang, Jie Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association between lincRNA expression and overall survival for patients with triple-negative breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Breast Cancer Res Treat (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10549-020-06021-6"}], "href": "https://doi.org/10.1007/s10549-020-06021-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33247368"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33247368"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yu Wang, Junfeng Fu, Ze Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Screening key lncRNAs for human lung adenocarcinoma based on machine learning and weighted gene co-expression network analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biomark (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/CBM-190225"}], "href": "https://doi.org/10.3233/CBM-190225"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31322548"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31322548"}]}]}]}