{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNAs (lncRNAs) have emerged as key regulators of tumor progression, and recent work highlights the role of LINC01271 in this context. In breast cancer, LINC01271—identified as the human ortholog of the murine MaTAR25—acts as a nuclear, chromatin‐associated scaffold that binds to purine rich element binding protein B (PURB) to modulate the transcription of Tensin1 (Tns1). Tns1 is an essential component of focal adhesions, linking signals from the extracellular matrix to the actin cytoskeleton; thus, disruption of Tns1 expression following LINC01271 (MaTAR25) loss leads to a reorganization of the actin network and a reduction in focal adhesions and microvilli, ultimately impairing tumor cell proliferation, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, transcriptome analyses in renal cell carcinoma have identified LINC01271 as one of several lncRNAs exhibiting significant dysregulation (specifically, down-regulation) in tumor tissue relative to non-tumor tissue, although its precise functional contribution in this context remains to be fully elucidated compared to other more prominently studied lncRNAs like PVT1 and LUCAT1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Our recent studies further support the central role of lncRNAs in modulating cancer cell behavior, reinforcing the concept that LINC01271 may serve not only as a valuable biomarker for poor prognosis and metastasis in breast cancer but also as a potential therapeutic target across diverse cancer types."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kung-Chi Chang, Sarah D Diermeier, Allen T Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MaTAR25 lncRNA regulates the Tensin1 gene to impact breast cancer progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-020-20207-y"}], "href": "https://doi.org/10.1038/s41467-020-20207-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33353933"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33353933"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Julia Bohosova, Marek Kasik, Adela Kubickova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA PVT1 is increased in renal cell carcinoma and affects viability and migration in vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Lab Anal (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcla.24442"}], "href": "https://doi.org/10.1002/jcla.24442"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35441392"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35441392"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Kung-Chi Chang, David L Spector "}, {"type": "b", "children": [{"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "MaTAR25"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": ": a long non-coding RNA involved in breast cancer progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/23723556.2021.1882286"}], "href": "https://doi.org/10.1080/23723556.2021.1882286"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33860086"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33860086"}]}]}]}