{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01272 is a long non‐coding RNA that exhibits context‐dependent expression and functional roles across a spectrum of diseases. In inflammatory bowel disease, LINC01272 is consistently upregulated in both tissue and plasma samples, and its enhanced expression has been linked to a pro‐inflammatory myeloid signature as well as more severe mucosal injury, indicating its potential utility as a diagnostic biomarker in conditions such as Crohn’s disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the cardiovascular arena, LINC01272—termed PELATON in this context—is highly expressed in monocytes and macrophages within unstable atherosclerotic plaques. Its predominantly nuclear localization and regulatory influence on phagocytosis, lipid uptake, and oxidative stress (via modulation of key mediators such as CD36) suggest that it contributes to plaque progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In malignancies, the function of LINC01272 appears to be tissue specific. In gastric cancer, LINC01272 is overexpressed, where it promotes cell migration and invasion by modulating the expression of epithelial–mesenchymal transition–related proteins, thereby correlating with advanced clinical features such as lymph node metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Conversely, in lung cancer, LINC01272 is downregulated and acts as a tumor suppressor. In lung cancer models its overexpression inhibits cell viability, proliferation, migration, and invasion via distinct microRNA regulatory axes – one involving miR-7-5p/CRLS1 and another mediated through miR-1303 – with decreased expression being associated with poorer clinical outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sen Wang, Yong Hou, Weiping Chen, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Long ncRNA Landscape in the Ileum of Treatment-Naive Early-Onset Crohn Disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Inflamm Bowel Dis (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/ibd/izx013"}], "href": "https://doi.org/10.1093/ibd/izx013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29361088"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29361088"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "John Hung, Jessica P Scanlon, Amira D Mahmoud, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel Plaque Enriched Long Noncoding RNA in Atherosclerotic Macrophage Regulation (PELATON)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/ATVBAHA.119.313430"}], "href": "https://doi.org/10.1161/ATVBAHA.119.313430"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31826651"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31826651"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xue Leng, Geli Liu, Sen Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01272 Promotes Migration and Invasion of Gastric Cancer Cells via EMT."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Onco Targets Ther (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/OTT.S242073"}], "href": "https://doi.org/10.2147/OTT.S242073"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32368096"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32368096"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xuan Ma, Yang Liu, Hao Tian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01272 Suppressed Cell Multiplication and Induced Apoptosis Via Regulating MiR-7-5p/CRLS1 Axis in Lung Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Microbiol Biotechnol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4014/jmb.2102.02010"}], "href": "https://doi.org/10.4014/jmb.2102.02010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34099597"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34099597"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Sue Zhang, Jielu Zhou "}, {"type": "b", "children": [{"type": "t", "text": "Low LINC01272 predicts poor prognosis of non-small cell lung cancer and its biological function in tumor cells by inhibiting miR-1303."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Lett (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ol.2021.12913"}], "href": "https://doi.org/10.3892/ol.2021.12913"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34386074"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34386074"}]}]}]}