{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent evidence highlights the oncogenic function of long intergenic non‐protein coding RNA 1273 (LINC01273) in multiple malignancies. In hepatocellular carcinoma (HCC), LINC01273 is significantly overexpressed in tumor tissues as well as in cells resistant to sorafenib, a first‐line treatment for advanced HCC, where its upregulation is associated with poorer overall and relapse‐free survival. Functional studies demonstrated that silencing LINC01273 in sorafenib‐resistant HCC cell lines impaired viability, colony formation, and DNA synthesis, indicating its pivotal role in mediating drug resistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, in esophageal squamous cell carcinoma (ESCC), LINC01273 emerged as a component of a six‐lncRNA prognostic signature that outperformed traditional TNM staging in survival prediction. Subsequent experimental validation confirmed that LINC01273 may exert oncogenic effects in ESCC, further underlining its relevance as a potential biomarker for patient prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Huifang Kong, Jie Sun, Wei Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long intergenic non-protein coding RNA 1273 confers sorafenib resistance in hepatocellular carcinoma via regulation of methyltransferase 3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2022.2025701"}], "href": "https://doi.org/10.1080/21655979.2022.2025701"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35037556"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35037556"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ze-Jun Zheng, Yan-Shang Li, Jun-De Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Construction of the Six-lncRNA Prognosis Signature as a Novel Biomarker in Esophageal Squamous Cell Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2022.839589"}], "href": "https://doi.org/10.3389/fgene.2022.839589"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35432441"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35432441"}]}]}]}