{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNA LINC01278 exhibits context‐dependent roles in human diseases and displays diverse regulatory mechanisms. In colorectal cancer, LINC01278 is upregulated and promotes tumor progression by sponging miR‐134, thereby releasing repression of KDM2A and enhancing cell viability, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In vascular smooth muscle cells during aortic dissection, in contrast, LINC01278 is downregulated; its overexpression attenuates phenotypic switching by binding miR‐500b‐5p to regulate ACTG2 expression, suggesting a protective role."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In papillary thyroid carcinoma, LINC01278 is downregulated and functions as a tumor suppressor. It acts as a competing endogenous RNA (ceRNA) by sequestering miR‐376c‐3p to positively regulate DNM3 expression, thereby inhibiting proliferation and metastasis and modulating the epithelial–mesenchymal transition. In addition, LINC01278 is transcriptionally activated by the β‐catenin/LEF‐1 complex and in turn promotes β‐catenin ubiquitination and degradation, establishing a negative feedback loop on Wnt/β‐catenin signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In laryngeal cancer, LINC01278 plays an oncogenic role by suppressing miR‐185‐5p, which results in enhanced expression of CST1 and subsequent stimulation of proliferation, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In hepatocellular carcinoma, a β‐catenin/TCF‐4–LINC01278–miR‐1258–Smad2/3 feedback loop contributes to metastasis, with LINC01278 acting as a negative regulator of miR‐1258 to ultimately facilitate TGF‐β/Smad signaling and cell dissemination."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In osteosarcoma, LINC01278 is overexpressed and associated with poor prognosis. It promotes tumor growth by acting as a ceRNA: one study demonstrates that LINC01278 modulates the miR‐134‐5p/KRAS axis, while another shows that it sponges miR‐133a‐3p to release PTHR1, thereby enhancing proliferation and inhibiting apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond these mechanistic insights, LINC01278 has also been identified as part of RNA signatures with diagnostic and prognostic potential. It has been incorporated into ceRNA regulatory networks in type 1 diabetes mellitus"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "and as a component of an eight‐lncRNA prognostic signature in childhood acute lymphoblastic leukemia."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings highlight the multifaceted functions of LINC01278 in regulating cell proliferation, differentiation, and metastasis. Its role, either as an oncogene or tumor suppressor, is highly dependent on the cellular context, underscoring its promise as a potential therapeutic target and biomarker in various clinical settings.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "C Xi, N-Y Ye, Y-B Wang "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA LINC01278 accelerates colorectal cancer progression via miR-134-5p/KDM2A axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202010_23405"}], "href": "https://doi.org/10.26355/eurrev_202010_23405"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33155208"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33155208"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Weitie Wang, Qing Liu, Yong Wang, et al. 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