{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long intergenic non‐protein coding RNA 1279 (LINC01279) has emerged as an important regulatory molecule involved in several disease processes. In endometriosis, for example, LINC01279 is significantly upregulated and appears to promote pathogenic progression by acting as a mediator of the cell cycle. In one study, its elevated expression was linked to key factors such as cyclin‐dependent kinase 14 and C‑X‑C motif chemokine ligand 12, suggesting a role in facilitating abnormal cell proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Another investigation in endometriosis models revealed that LINC01279 can target miR‑135b, leading to the downregulation of HOXA10 and thereby contributing to disease advancement."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond the context of endometriosis, LINC01279 is also implicated in cancer biology. It is highly expressed in gastric cancer tissues and patient serum, with its levels correlating significantly with aggressive tumor features such as vascular invasion, nerve invasion, advanced tumor stage, and lymph node metastasis. This association with poorer overall survival underscores its potential utility as a prognostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, in studies of ocular disorders like strabismus, LINC01279 was one of the few long non-coding RNAs identified with specific enrichment in extracellular functions, suggesting a possible role in cell surface or extracellular signaling processes that may contribute to the disease pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings indicate that LINC01279 may regulate key cellular processes—including cell cycle progression and gene expression modulation via microRNA interactions—in a tissue-dependent manner. These multifaceted roles in endometriosis, gastric cancer, and potentially other conditions support further investigation into LINC01279 as both a mechanistic contributor to disease and a promising therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jie Liu, Qi Wang, Rongrong Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of LINC01279 as a cell cycle‑associated long non‑coding RNA in endometriosis with GBA analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2018.9387"}], "href": "https://doi.org/10.3892/mmr.2018.9387"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30106115"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30106115"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Liling Liu, Junping Cheng, Fu Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lnc-RNA LINC01279 induces endometriosis via targeting of HOXA10."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Obstet Gynaecol Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jog.14723"}], "href": "https://doi.org/10.1111/jog.14723"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33657670"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33657670"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Song Meng, Ponnie Robertlee Dolo, Pei Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The expression of long non-coding RNA LINC01279 in gastric adenocarcinoma and its clinical significance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Asian J Surg (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.asjsur.2021.08.031"}], "href": "https://doi.org/10.1016/j.asjsur.2021.08.031"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34507839"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34507839"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Wen-Xiu Ma, Xiao-Gang Huang, Tian-Ke Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of dysregulated coding and long non‑coding RNAs in the pathogenesis of strabismus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2018.8832"}], "href": "https://doi.org/10.3892/mmr.2018.8832"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29620205"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29620205"}]}]}]}