{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01281 has emerged as an immune‐related long non‐coding RNA with a potential dual role in cancer. In laryngeal cancer, LINC01281 was identified as part of a 4‐lncRNA prognostic signature and appears to act as a protective factor. Functional annotations suggest that its activity may involve modulation of key pathways—including the Notch and Wnt signaling cascades as well as voltage‐gated calcium channels—that are critical in regulating tumor apoptosis, metastasis, invasion, and immunity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In cervical cancer, LINC01281 is included within an 8‐lncRNA signature that correlates with disease progression and overall survival. Importantly, experimental validation using T‐cell chemotaxis assays demonstrated that LINC01281 significantly enhances the migration of T cells toward cancer cells, suggesting that it may facilitate a beneficial immune cell infiltration and thereby influence the tumor microenvironment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Although the abstract discussing general immune responses provides contextual insight into the diverse roles of immune-regulatory lncRNAs, it further supports the notion that molecules like LINC01281 contribute to the complex interplay between tumor cells and the immune system."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Guihai Zhang, Erxi Fan, Qiuyue Zhong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and potential mechanisms of a 4-lncRNA signature that predicts prognosis in patients with laryngeal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Genomics (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s40246-019-0230-6"}], "href": "https://doi.org/10.1186/s40246-019-0230-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31416476"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31416476"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jing Ye, Xiaojing Chen, Weiguo Lu "}, {"type": "b", "children": [{"type": "t", "text": "Identification and Experimental Validation of Immune-Associate lncRNAs for Predicting Prognosis in Cervical Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Onco Targets Ther (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/OTT.S322998"}], "href": "https://doi.org/10.2147/OTT.S322998"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34526775"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34526775"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Magdalena Niedzielska, Elisabeth Israelsson, Bastian Angermann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential gene expression in human tissue resident regulatory T cells from lung, colon, and blood."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.26322"}], "href": "https://doi.org/10.18632/oncotarget.26322"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30546835"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30546835"}]}]}]}