{"type": "root", "children": [{"type": "t", "text": "<head>\n <meta charset=\"UTF-8\">\n <title>Summary: Role of LINC01287 in Cancer Progression</title>\n </head>\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Long intergenic noncoding RNA LINC01287 has emerged as an oncogenic regulator in multiple cancer types. It modulates cell proliferation, apoptosis, migration, and invasion by acting as a competitive endogenous RNA (ceRNA) that sequesters tumor‐suppressive microRNAs, leading to the upregulation of various oncogenic effectors.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In breast cancer, LINC01287 is markedly overexpressed and its aberrant levels are correlated with advanced TNM stage, lymph node metastasis, and poorer overall survival. Functional studies reveal that silencing LINC01287 inhibits cell proliferation and metastasis, with evidence suggesting involvement of the Wnt/β-catenin pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In hepatocellular carcinoma (HCC), multiple independent studies report that LINC01287 is upregulated. In this context, LINC01287 acts as a ceRNA by binding and suppressing miR-298, which in turn leads to the derepression of downstream targets such as MYB and STAT3. In addition, another study has implicated the miR-559/TCF12 axis in mediating its pro-tumorigenic effect. Collectively, these findings indicate that LINC01287 contributes to HCC cell growth, migration, and invasion, underscoring its potential as a prognostic biomarker and therapeutic target."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In lung adenocarcinoma, LINC01287 promotes cell proliferation while inhibiting apoptosis by competitively binding to miR-3529-5p, which results in the posttranscriptional upregulation of RNASEH2A. Its transcription is further induced by FOXA1, reinforcing its role in lung tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Moreover, inclusion of LINC01287 in a six-lncRNA prognostic signature has linked its expression to lung cancer metastasis and patient prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In colon cancer, elevated LINC01287 levels are associated with advanced TNM stage, lymph node and distant metastasis, and reduced overall survival. Mechanistically, LINC01287 functions as a molecular sponge for miR-4500, thereby enhancing MAP3K13 expression and triggering NF-κB pathway activation, which ultimately promotes epithelial–mesenchymal transition and tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these studies highlight the critical oncogenic role of LINC01287 across diverse cancer types. Its ability to modulate key signaling pathways via ceRNA mechanisms reinforces its promise as both a prognostic biomarker and a potential therapeutic target in cancer management.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "C Song, P Sun, Q He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LINC01287 promotes breast cancer cells proliferation and metastasis by activating Wnt/ß-catenin signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201905_17928"}], "href": "https://doi.org/10.26355/eurrev_201905_17928"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31173295"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31173295"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yichao Mo, Longguang He, Zeru Lai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01287 regulates tumorigenesis and invasion via miR-298/MYB in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.13818"}], "href": "https://doi.org/10.1111/jcmm.13818"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30133116"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30133116"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yichao Mo, Longguang He, Zeru Lai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01287/miR-298/STAT3 feedback loop regulates growth and the epithelial-to-mesenchymal transition phenotype in hepatocellular carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-018-0831-2"}], "href": "https://doi.org/10.1186/s13046-018-0831-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30001751"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30001751"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Y-B Song, Z Yu, A-Q Fu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Proliferation and migration of hepatocellular carcinoma are accelerated by LINC01287 via the miR-559/TCF12 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202006_21496"}], "href": "https://doi.org/10.26355/eurrev_202006_21496"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32572916"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32572916"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jing Zhang, Dan Ma, Honggang Kang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA LINC01287 promotes proliferation and inhibits apoptosis of lung adenocarcinoma cells via the miR-3529-5p/RNASEH2A axis under the competitive endogenous RNA pattern."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Environ Toxicol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/tox.23325"}], "href": "https://doi.org/10.1002/tox.23325"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34254728"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34254728"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Qing Cao, Zewen Dong, Shuzhen Liu, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "LINC01287 facilitates proliferation, migration, invasion and EMT of colon cancer cells via miR-4500/MAP3K13 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-021-08528-7"}], "href": "https://doi.org/10.1186/s12885-021-08528-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34229645"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34229645"}]}]}]}