{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNAs (lncRNAs) have emerged as key regulators of non‐small cell lung cancer (NSCLC) progression, and one such molecule, LINC01288, has been recently characterized for its oncogenic function. Specifically, LINC01288 is frequently upregulated in NSCLC tissues and cell lines, where it enhances cell viability, migration, xenograft tumor growth, and metastasis both in vitro and in vivo."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Mechanistic investigations reveal that LINC01288 physically binds to interleukin‐6 (IL‑6) mRNA, thereby stabilizing the transcript and sustaining an autocrine IL‑6 loop that leads to enhanced STAT3 activation; this IL‑6/STAT3 axis is instrumental in driving NSCLC progression. In the broader context of lncRNAs in NSCLC, such molecules are recognized for modulating key processes underlying metastasis through mechanisms including interaction with microRNAs (as competing endogenous RNAs), binding to target proteins, and engaging in diverse signaling cascades."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Cuixia Bian, Luna Yuan, Huirong Gai "}, {"type": "b", "children": [{"type": "t", "text": "A long non-coding RNA LINC01288 facilitates non-small cell lung cancer progression through stabilizing IL-6 mRNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.04.132"}], "href": "https://doi.org/10.1016/j.bbrc.2019.04.132"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31054777"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31054777"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Cheng Fang, Lixin Wang, Chenyuan Gong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNAs: How to regulate the metastasis of non-small-cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.15054"}], "href": "https://doi.org/10.1111/jcmm.15054"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32048814"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32048814"}]}]}]}