{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01291 has emerged as an important regulatory long non‐coding RNA with varied functions in different disease contexts. In hepatocellular carcinoma, LINC01291 is significantly upregulated and acts as an oncogenic driver by promoting cell proliferation, migration, invasion, and epithelial–mesenchymal transition. Mechanistically, it functions as a competing endogenous RNA that sponges miR‑186‑5p, thereby relieving the miRNA‑mediated repression of oxidative stress‑responsive 1 (OXSR1) and facilitating tumor progression. In contrast, while not directly implicated in chronic kidney disease pathways—as illustrated in extensive genome‐wide expression analyses—the differential expression of LINC01291 in umbilical cord blood from fetal growth restriction cases suggests its potential as a candidate biomarker for intrauterine growth disturbances. These findings underscore the context‐dependent functions of LINC01291, acting both as an oncogenic regulator in liver cancer and as part of a broader transcriptional signature associated with adverse fetal outcomes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jian Chu, Guangyong Geng, Xiaoming Ai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01291 promotes hepatocellular carcinoma development by targeting the miR-186-5p/OXSR1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gene Med (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jgm.3394"}], "href": "https://doi.org/10.1002/jgm.3394"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34665488"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34665488"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiaoguang Xu, James M Eales, Artur Akbarov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular insights into genome-wide association studies of chronic kidney disease-defining traits."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-018-07260-4"}], "href": "https://doi.org/10.1038/s41467-018-07260-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30467309"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30467309"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Guiying Wang, Jun Yu, Yiwei Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Whole-transcriptome sequencing uncovers core regulatory modules and gene signatures of human fetal growth restriction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Transl Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s40169-020-0259-0"}], "href": "https://doi.org/10.1186/s40169-020-0259-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31993806"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31993806"}]}]}]}