{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01293 is a long non‐coding RNA that has been implicated in processes related to environmental stress responses and cellular regulation. In one study focused on the tumor microenvironment, acidic and hypoxic conditions—both of which are key drivers in carcinogenesis—were shown to influence complex regulatory networks; although the abstract was truncated, it suggests that lncRNAs such as LINC01293 may play a regulatory role in adapting gene expression and cellular metabolism in response to these harsh conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In a separate investigation of fetal growth restriction (FGR), comprehensive transcriptomic profiling of umbilical cord blood identified a range of dysregulated lncRNAs that are involved in metabolic, neural, cardiac, and immune functions. Although this study specifically highlighted candidates including LINC01291, by analogy, lncRNAs like LINC01293 might also contribute to the regulatory networks that affect intrauterine growth and development, thereby possibly serving as candidate signatures for pathological conditions when their expression is altered."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Geovana Calvo-Anguiano, Jose J Lugo-Trampe, Alberto Camacho, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comparison of specific expression profile in two "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "in vitro"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " hypoxia models."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Ther Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/etm.2018.6048"}], "href": "https://doi.org/10.3892/etm.2018.6048"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29805495"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29805495"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Guiying Wang, Jun Yu, Yiwei Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Whole-transcriptome sequencing uncovers core regulatory modules and gene signatures of human fetal growth restriction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Transl Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s40169-020-0259-0"}], "href": "https://doi.org/10.1186/s40169-020-0259-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31993806"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31993806"}]}]}]}