{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Dysregulation of long non‐coding RNAs (lncRNAs) has been increasingly linked to cancer development and progression. In one study of bladder cancer, a novel oncogenic lncRNA—referred to as LINC01296 (likely intended by “LINC01297”)—was found to be overexpressed, and its silencing significantly reduced cell viability and migratory capacity. These functional analyses suggest that LINC01296 contributes to an aggressive cancer phenotype by modulating mRNA networks and interacting with proteins essential for translation initiation and other post‐transcriptional modifications."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Broad transcriptomic surveys in breast cancer have also demonstrated that aberrantly expressed lncRNAs define distinct molecular subgroups and correlate with the activation of key signaling pathways, underscoring their regulatory roles in cell proliferation, migration and epithelial-to-mesenchymal transition."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, comprehensive reviews have highlighted that lncRNAs function at multiple layers of gene regulation—including transcriptional initiation, post-transcriptional processing, and epigenetic modifications—thereby impacting tissue homeostasis and disease etiology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings emphasize the importance of oncogenic lncRNAs such as LINC01296 in driving tumor progression. Their ability to orchestrate key cellular processes makes them attractive candidates for biomarker development and targeted therapeutic interventions.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Anna Katharina Seitz, Lise Lotte Christensen, Emil Christensen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Profiling of long non-coding RNAs identifies LINC00958 and LINC01296 as candidate oncogenes in bladder cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-017-00327-0"}], "href": "https://doi.org/10.1038/s41598-017-00327-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28341852"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28341852"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Olivier Van Grembergen, Martin Bizet, Eric J de Bony, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Portraying breast cancers with long noncoding RNAs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Adv (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/sciadv.1600220"}], "href": "https://doi.org/10.1126/sciadv.1600220"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27617288"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27617288"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Andrew J Warburton, David N Boone "}, {"type": "b", "children": [{"type": "t", "text": "Insights from Global Analyses of Long Noncoding RNAs in Breast Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Pathobiol Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s40139-017-0122-1"}], "href": "https://doi.org/10.1007/s40139-017-0122-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28616363"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28616363"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Guoku Hu, Fang Niu, Bree A Humburg, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular mechanisms of long noncoding RNAs and their role in disease pathogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.24307"}], "href": "https://doi.org/10.18632/oncotarget.24307"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29719633"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29719633"}]}]}]}