{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNAs (lncRNAs) have emerged as pivotal regulators of gene expression through epigenetic mechanisms in diverse cancers. In the context of colon adenocarcinoma, one such lncRNA – LINC01301 – appears to contribute to the modulation of DNA methylation patterns that underlie gene dysregulation in tumorigenesis. Comprehensive analysis utilizing LASSO regression identified LINC01301 among a group of lncRNAs whose expression levels are linked to overall survival. In turn, its inclusion in a methylation‐based prognostic predictive system underscores its potential utility both as a biomarker and as a functional mediator in the epigenetic regulation of pathogenic mechanisms. Further functional enrichment studies of its co‐expressed genes have provided insight into the biological pathways associated with colon cancer progression, emphasizing LINC01301’s role in orchestrating epigenetic modifications that affect disease outcome."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Qiongying Zhang, Zhuo Lin, Haiyan Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prediction of overall survival time in patients with colon adenocarcinoma using DNA methylation profiling of long non-coding RNAs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Lett (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ol.2019.11236"}], "href": "https://doi.org/10.3892/ol.2019.11236"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32002035"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32002035"}]}]}]}