{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNA LINC01305 has emerged as an oncogenic regulator in several cancers. In cervical cancer, its expression is significantly elevated and correlates with lower patient survival. Functionally, LINC01305 promotes cell proliferation, migration, invasion, and enhances stemness. Mechanistically, one study revealed that LINC01305 not only interacts with the RNA‐binding protein KHSRP and is secreted via exosomes to facilitate intercellular communication but also acts as a competitive endogenous RNA that sponges miR‑129‑5p, thereby de‐repressing Sox4 expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In esophageal squamous cell carcinoma, LINC01305 is highly expressed and predominantly localized in the cytoplasm, where it promotes metastasis and proliferation. This effect is mediated by the stabilization of HTR3A mRNA through direct interactions with the mRNA‐stabilizing proteins IGF2BP2 and IGF2BP3."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Similarly, in non‑small cell lung cancer, elevated levels of LINC01305 are associated with larger tumor sizes, advanced tumor stage, and poorer overall survival. Its oncogenic role in this context is linked to the modulation of the epithelial–mesenchymal transition via regulation of the TNXB‐mediated PI3K/Akt signaling pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, large‐scale profiling of dysregulated long non‑coding RNAs in head and neck squamous cell carcinoma emphasizes the broader clinical relevance of aberrant lncRNA expression in cancer, further underscoring the potential of molecules like LINC01305 as diagnostic and therapeutic targets."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies indicate that LINC01305 functions as a key mediator of cancer progression by engaging in diverse molecular mechanisms—ranging from modulating mRNA stability and protein interactions to acting as a ceRNA—and suggest that it may serve as a promising prognostic biomarker and therapeutic target in multiple tumor types.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xianxia Huang, Xuemei Liu, Bo Du, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA LINC01305 promotes cervical cancer progression through KHSRP and exosome-mediated transfer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.202565"}], "href": "https://doi.org/10.18632/aging.202565"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33638945"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33638945"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yuexun Xu, Haiyan Zhu, Hongbin Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01305 inhibits malignant progression of cervical cancer via miR-129-5p/Sox4 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Transl Res (2020)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33312390"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33312390"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Guo-Wei Huang, Qian-Qian Chen, Chang-Chun Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "linc01305 promotes metastasis and proliferation of esophageal squamous cell carcinoma through interacting with IGF2BP2 and IGF2BP3 to stabilize HTR3A mRNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biochem Cell Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biocel.2021.106015"}], "href": "https://doi.org/10.1016/j.biocel.2021.106015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34022433"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34022433"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "F Yan, S W Liu, X Y Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing LncRNA LINC01305 inhibits epithelial mesenchymal transition in lung cancer cells by regulating TNXB-mediated PI3K/Akt signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Regul Homeost Agents (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.23812/20-73-A-33"}], "href": "https://doi.org/10.23812/20-73-A-33"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32549529"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32549529"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Nijiro Nohata, Martin C Abba, J Silvio Gutkind "}, {"type": "b", "children": [{"type": "t", "text": "Unraveling the oral cancer lncRNAome: Identification of novel lncRNAs associated with malignant progression and HPV infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oral Oncol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.oraloncology.2016.05.014"}], "href": "https://doi.org/10.1016/j.oraloncology.2016.05.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27424183"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27424183"}]}]}]}