{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Two independent studies provide insights into the potential roles of LINC01310. In one study examining copy number alterations in hereditary breast and ovarian tumors (BRCAX), recurrent gains and losses on several chromosomes were characterized; however, no direct functional role was attributed to LINC01310 in tumorigenesis in that context."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In contrast, a genome‐wide association study investigating serum levels of mineral elements identified a genetic locus spanning LINC01310 as significantly associated with serum copper concentration. This association suggests that LINC01310 may have a regulatory role in copper homeostasis, highlighting its potential involvement in mineral metabolism."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, while LINC01310 was not functionally implicated in the cancer-related genomic alterations observed in the BRCAX tumors, its variation appears to be linked to the regulation of serum copper levels, pointing to a possible role in maintaining mineral balance.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Paula Silva Felicio, Lucas Tadeu Bidinotto, Matias Eliseo Melendez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic alterations detected by comparative genomic hybridization in BRCAX breast and ovarian cancers of Brazilian population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.25537"}], "href": "https://doi.org/10.18632/oncotarget.25537"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29938003"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29938003"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Duojian Guo, Yu Zhou, Xingwei Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Preliminary study of genome-wide association identifies novel susceptibility genes for serum mineral elements in the Chinese Han population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Trace Elem Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12011-021-02854-4"}], "href": "https://doi.org/10.1007/s12011-021-02854-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34417961"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34417961"}]}]}]}