{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01312 emerges as a gene of interest in two distinct contexts. In a study of otofaciocervical syndrome (OTFCS), a chromosomal deletion in 6q23—identified in a mother–daughter pair presenting with facial dysmorphisms, ear abnormalities with hearing loss, and shoulder girdle anomalies—highlighted a minimal overlapping region that includes LINC01312, suggesting that its loss or altered regulation may contribute to the OTFCS phenotype through disruption of developmental pathways, potentially linked to the Pax‐Six‐Eya‐Dach network."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In a separate study focused on lung adenocarcinoma (LAC), LINC01312 was one of ten genes identified via multivariate Cox regression modeling that stratified patients into distinct risk groups with differences in long-term outcomes. Here, the expression level of LINC01312—when integrated into a risk score staging system—proved to be a significant prognostic marker, distinguishing between high-risk patients with poorer outcomes and low-risk patients with better survival prospects."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Simone Gana, Angelo Valetto, Benedetta Toschi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Familial Interstitial 6q23.2 Deletion Including Eya4 Associated With Otofaciocervical Syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2019.00650"}], "href": "https://doi.org/10.3389/fgene.2019.00650"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31379922"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31379922"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yan-Yan Li, Chun Yang, Pingting Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-scale analysis to identify prognostic markers and predict the survival of lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.27144"}], "href": "https://doi.org/10.1002/jcb.27144"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30105759"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30105759"}]}]}]}