{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01315 is emerging as an important long non‐coding RNA with context‐dependent functions in multiple types of cancers. In colorectal cancer, several studies have shown that LINC01315 is overexpressed and promotes tumor progression by enhancing cell proliferation, migration, invasion, epithelial–mesenchymal transition, and cancer stem cell characteristics. Mechanistically, in colorectal cancer it has been demonstrated to function as a competing endogenous RNA (ceRNA) by “sponging” microRNAs (e.g., miR‑205‑3p), thereby upregulating downstream effectors such as PRKAA1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, in papillary thyroid cancer, LINC01315 overexpression facilitates growth and invasion through direct interaction with and sequestration of miR‑497‑5p."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In triple‑negative breast cancer and broader breast cancer contexts, LINC01315 is frequently upregulated and has been associated with aggressive clinicopathological features, including vessel invasion and poor prognosis, suggesting its potential as an independent prognostic marker."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": " In contrast, evidence from studies in oral squamous cell carcinoma indicates that LINC01315, which is expressed at lower levels compared to normal tissues, exerts tumor‐suppressive effects by sequestering miR‑211. This interaction leads to the upregulation of DLG3 and subsequent activation of the Hippo signaling pathway, resulting in reduced proliferation, migration, and invasion, as well as enhanced apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Additional studies that have incorporated LINC01315 into prognostic signatures for cancers such as stomach adenocarcinoma further underscore its potential value as a biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Moreover, investigations into its role in colorectal cancer stem-like cell biology and exosome-mediated communication are expanding our understanding of its multifaceted role in tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, LINC01315 acts as an oncogenic factor in colorectal, thyroid, and certain breast cancers by modulating cell growth, invasion, and stemness through miRNA sponging and downstream target regulation, while in oral squamous cell carcinoma it appears to function as a tumor suppressor. These context-dependent actions render LINC01315 a promising candidate for further investigation as a prognostic biomarker and potential therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Rong Liang, Jun Zhang, Ru Meng Zhang, et al. 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