{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent investigations into molecular biomarkers have revealed distinct roles for long non‐coding RNAs (lncRNAs) across diverse disease settings. In one study focused on alcohol use disorder and its association with accelerated epigenetic aging—assessed via Levine’s DNAm PhenoAge and genome‐wide analyses—a range of genetic factors were explored for their contribution to age acceleration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although this study did not directly elaborate on the function of LINC01317, another investigation into papillary renal cell carcinoma (pRCC) identified LINC01317 as one of ten cancer‐related lncRNAs that were independently associated with patient prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In the pRCC study, these lncRNAs were integrated into a prognostic risk model that effectively stratified patients into high‐ and low‐risk groups based on various clinical parameters, including tumor stage and survival outcomes. LINC01317’s inclusion in this signature suggests that its dysregulation may be linked to tumor progression and could serve as a useful biomarker for prognosis, warranting further mechanistic studies into its role in cancer biology.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Audrey Luo, Jeesun Jung, Martha Longley, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epigenetic aging is accelerated in alcohol use disorder and regulated by genetic variation in APOL2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuropsychopharmacology (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41386-019-0500-y"}], "href": "https://doi.org/10.1038/s41386-019-0500-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31466081"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31466081"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Binghai Chen, Di Dong, Qin Yao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel prognostic cancer-related lncRNA signature in papillary renal cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell Int (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12935-021-02247-6"}], "href": "https://doi.org/10.1186/s12935-021-02247-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34663322"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34663322"}]}]}]}