{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01320 is emerging as an oncogenic long non‐coding RNA with diverse roles in cancer and reproductive biology. In gastric cancer, elevated LINC01320 expression promotes malignant behaviors—including increased cell proliferation, migration, and invasion—through interactions with microRNAs such as miR‐495–5p and regulation of targets like RAB19."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In pancreatic cancer, high LINC01320 levels correlate with poor patient prognosis, and its knockdown suppresses tumor cell growth, migration, and invasiveness likely via targeted regulation of miR‐324–3p."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, in the context of endometrial receptivity, transcriptomic profiling that adjusts for cellular heterogeneity has identified LINC01320 as a novel gene potentially involved in endometrial maturation, underscoring its emerging relevance beyond classical oncogenic settings."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Although a separate comprehensive single‐cell analysis of human placental and decidual tissues provides valuable insights into intercellular communication during early gestation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", it does not specifically address LINC01320. Collectively, these studies suggest that LINC01320 plays context‐dependent regulatory roles—in some cases driving malignant progression by modulating critical microRNA pathways, and in others serving as a potential biomarker in reproductive tissue remodeling and function.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Naijun Hu, Hong Ji "}, {"type": "b", "children": [{"type": "t", "text": "N6-methyladenosine (m6A)-mediated up-regulation of long noncoding RNA LINC01320 promotes the proliferation, migration, and invasion of gastric cancer via miR495-5p/RAB19 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1953210"}], "href": "https://doi.org/10.1080/21655979.2021.1953210"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34288797"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34288797"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hua Meng, Kun Guo, Yun Zhang "}, {"type": "b", "children": [{"type": "t", "text": "Effects of lncRNA LINC01320 on Proliferation and Migration of Pancreatic Cancer Cells through Targeted Regulation of miR-324-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Healthc Eng (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/4125432"}], "href": "https://doi.org/10.1155/2021/4125432"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34976325"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34976325"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Marina Suhorutshenko, Viktorija Kukushkina, Agne Velthut-Meikas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Endometrial receptivity revisited: endometrial transcriptome adjusted for tissue cellular heterogeneity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Reprod (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/humrep/dey301"}], "href": "https://doi.org/10.1093/humrep/dey301"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30295736"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30295736"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hemant Suryawanshi, Pavel Morozov, Alexander Straus, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A single-cell survey of the human first-trimester placenta and decidua."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Adv (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/sciadv.aau4788"}], "href": "https://doi.org/10.1126/sciadv.aau4788"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30402542"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30402542"}]}]}]}