{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In melanoma, LINC01324 has been identified as a component of a prognostic long non-coding RNA (lncRNA) signature that can effectively stratify patient risk."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the study, LINC01324 was one of six lncRNAs whose differential expression significantly correlated with key oncogenic pathways. Specifically, the signature was linked to the regulation of the MAPK pathway, neurotrophin signaling, focal adhesion, and immune as well as inflammation‐related processes—pathways known to play critical roles in melanoma progression and patient prognosis. Although another study established a separate lncRNA-related competing endogenous RNA (ceRNA) network and prognostic model in melanoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", LINC01324 was uniquely highlighted in the context of the six-lncRNA risk signature. These findings suggest that LINC01324 may contribute to melanoma pathobiology by modulating multiple signaling networks that influence tumor behavior, thereby emerging as a potential biomarker for patient outcome.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shuocheng Yang, Jianguo Xu, Xuan Zeng "}, {"type": "b", "children": [{"type": "t", "text": "A six-long non-coding RNA signature predicts prognosis in melanoma patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2018.4268"}], "href": "https://doi.org/10.3892/ijo.2018.4268"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29436619"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29436619"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Nian Liu, Zijian Liu, Xinxin Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive Analysis of a Competing Endogenous RNA Network Identifies Seven-lncRNA Signature as a Prognostic Biomarker for Melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2019.00935"}], "href": "https://doi.org/10.3389/fonc.2019.00935"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31649871"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31649871"}]}]}]}