{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations have revealed that the long non-coding RNA LINC01339 plays a tumor‐suppressive role in Wilms’ tumor. In this malignancy, LINC01339 expression is notably reduced while miR‑135b‑3p levels are elevated, suggesting an inverse relationship between the two. Mechanistically, LINC01339 acts as a molecular sponge by directly binding miR‑135b‑3p, thereby alleviating its inhibitory effect on ADH1C expression. Consequently, the upregulation of LINC01339 leads to increased ADH1C levels, which in turn suppresses the proliferation and migration of Wilms’ tumor cells. Functional studies have further demonstrated that overexpressing LINC01339 limits tumor growth both in vitro and in vivo, whereas enhanced miR‑135b‑3p expression promotes cancer progression—a process that can be reversed by restoring ADH1C levels. These findings establish the LINC01339/miR‑135b‑3p/ADH1C regulatory axis as a promising target for therapeutic intervention in Wilms’ tumor."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yang Yu, Yanfei Liu "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA LINC01339 Hinders the Development of Wilms' Tumor via MiR-135b-3p/ADH1C Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Horm Metab Res (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1055/a-2184-8945"}], "href": "https://doi.org/10.1055/a-2184-8945"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37890508"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37890508"}]}]}]}