{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent integrative genomic studies have begun to unveil the role of non‐coding RNA loci in complex metabolic traits. In a gene‐based association analysis performed on an Indian cohort studying lipid levels, the long non‐coding RNA LINC01340 was pinpointed as a novel locus associated with total cholesterol (TC) regulation. Although the mechanistic underpinnings remain to be fully elucidated, the identification of LINC01340 in the context of lipid homeostasis suggests that it may function as a regulatory element—potentially influencing gene transcription or epigenetic modifications in metabolically active tissues such as subcutaneous adipose tissue. This finding adds to a growing body of evidence linking non‐coding genomic regions with the modulation of cardiovascular and metabolic disease risk factors (3). While other studies have emphasized the importance of parental origin effects in complex trait regulation (1) and uncovered genetic contributors to conditions like chronic mountain sickness (2), the discovery of LINC01340’s association with TC underscores the expanding recognition of long non‐coding RNAs as critical players in the genetic architecture of metabolic traits.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n <small>\n Citations:"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "</small>\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sahar V Mozaffari, Jeanne M DeCara, Sanjiv J Shah, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Parent-of-origin effects on quantitative phenotypes in a large Hutterite pedigree."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Commun Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s42003-018-0267-4"}], "href": "https://doi.org/10.1038/s42003-018-0267-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30675526"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30675526"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Steven Gazal, Jose R Espinoza, Frédéric Austerlitz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Genetic Architecture of Chronic Mountain Sickness in Peru."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2019.00690"}], "href": "https://doi.org/10.3389/fgene.2019.00690"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31417607"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31417607"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Khushdeep Bandesh, Gauri Prasad, Anil K Giri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study of blood lipids in Indians confirms universality of established variants."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hum Genet (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s10038-019-0591-7"}], "href": "https://doi.org/10.1038/s10038-019-0591-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30911093"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30911093"}]}]}]}