{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01341 has been identified as a promising candidate biomarker in prostate cancer. In a genome‐wide DNA methylation study, it was one of eight novel markers found to be hypermethylated in tumor tissue compared to nonmalignant prostate specimens, suggesting that its epigenetic regulation is highly cancer‐specific and may contribute to distinguishing aggressive from indolent disease (1). Although the related investigation in thyroid cancer evaluated numerous dysregulated long noncoding RNAs and demonstrated that lncRNA alterations can have profound effects on tumor cell behavior, LINC01341 was not among those functionally characterized in this context (2). Thus, while current evidence highlights the diagnostic and potentially prognostic utility of LINC01341 based on its methylation profile in prostate cancer, its precise functional role in tumor biology awaits further elucidation."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Siri H Strand, Michal Switnicki, Mia Moller, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RHCG and TCAF1 promoter hypermethylation predicts biochemical recurrence in prostate cancer patients treated by radical prostatectomy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.14391"}], "href": "https://doi.org/10.18632/oncotarget.14391"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28052017"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28052017"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wei Lu, Yongcan Xu, Jiewei Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of differential expressed lncRNAs in human thyroid cancer by a genome-wide analyses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.1627"}], "href": "https://doi.org/10.1002/cam4.1627"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29923329"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29923329"}]}]}]}