{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01344 is a long non‐coding RNA located in an intergenic region on chromosome 1 that has recently emerged as a candidate for involvement in diverse disease processes. In one study examining coronary heart disease (CHD) in type 2 diabetes (T2D), a lead single nucleotide polymorphism (rs10911021) at this locus was linked to CHD risk, with the protective minor allele showing an unexpected association with lower levels of high‐density lipoprotein (HDL) cholesterol and reduced measures of HDL particle subclasses in T2D patients."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " This finding suggests that, although counterintuitive, the regulatory elements in this intergenic region—which may include LINC01344—could be modulating lipid metabolism pathways that contribute to CHD pathogenesis in T2D.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In a separate investigation into liver pathobiology, high‐throughput RNA sequencing of liver tissues from control, cirrhotic, and hepatocellular carcinoma (HCC) samples revealed a vast repertoire of long non‐coding RNAs, with a subset differentially expressed during HCC development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Among these, candidate lncRNAs such as LINC01344 were found to be co‐expressed with genes involved in cell cycle regulation, transforming growth factor‐β signaling, and liver metabolism, suggesting that they may participate in enhancer activity and transcriptional network rewiring during liver carcinogenesis.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, the emerging evidence supports a multifaceted role for LINC01344 as a regulatory RNA molecule. Its locus appears to contribute to complex metabolic regulation in T2D‐associated CHD—possibly via modulation of HDL particle traits—and to the transcriptional deregulation observed in HCC, underlining its potential as both a biomarker and a functional mediator in disease pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Katherine E Beaney, Jackie A Cooper, Stela McLachlan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Variant rs10911021 that associates with coronary heart disease in type 2 diabetes, is associated with lower concentrations of circulating HDL cholesterol and large HDL particles but not with amino acids."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cardiovasc Diabetol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12933-016-0435-0"}], "href": "https://doi.org/10.1186/s12933-016-0435-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27549350"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27549350"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Davide Degli Esposti, Hector Hernandez-Vargas, Catherine Voegele, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of novel long non-coding RNAs deregulated in hepatocellular carcinoma using RNA-sequencing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.7364"}], "href": "https://doi.org/10.18632/oncotarget.7364"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26887054"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26887054"}]}]}]}